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KMID : 1114620210180010036
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Journal of the Korean Society for Breast Screening
2021 Volume.18 No. 1 p.36 ~ p.46
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Recurrence in Stage I and II Triple-Negative Breast Cancer: Analysis of Clinicopathologic Factors and Imaging Findings
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Eom Hye-Jung
Cha Joo-Hee
Kim Hak-Hee
Shin Hee-Jung
Chae Eun-Young
Choi Woo-Jung
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Abstract
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Purpose: To describe the outcomes of patients with early stage triple-negative breast cancer (TNBC) and to investigate whether certain imaging and clinicopathologic factors were associated with recurrence in patients with early stage TNBC.
Materials and Methods: We identified 702 patients with stage I and II TNBC treated between 2009 and 2011. Data included patient and tumor characteristics, time of recurrence, and findings on mammography, ultrasonography (US), and magnetic resonance imaging (MRI).
Results: The study included 702 patients with mean age of 49.0 years, mean follow-up of 61 months and 115 (16.4%) had recurrence. Factors associated with recurrence included increasing tumor size, positive nodal status, ki-67 index more than 14, presence of lymphovascular invasion (LVI), mastectomy, neoadjuvant or adjuvant chemotherapy, moderate or marked background parenchymal enhancement on MRI. After controlling for all potential confounders, tumor size, nodal status, LVI, and adjuvant chemotherapy were independently associated with recurrence.
Conclusion: Sixteen percent of patients with early stage TNBC experienced recurrence, with the 3 and 5-year recurrence rates being 12.4% and 15.3%, respectively. Tumor size, nodal status, LVI, and adjuvant chemotherapy were independently associated with recurrence, while none of the imaging showed association.
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KEYWORD
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Breast, Triple-negative breast cancer, Recurrence, Mammography, Ultrasonography, Magnetic resonance imaging
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